64 GB of RAM DOES indeed work in a Mac Pro 2,1, check it out.
The original specs of the 2,1 Mac Pro states it can only accept up to 16 GB RAM, though, many sites include upgrade kits to 32 GB. With that being said, the 32 GB limit comes from the 32-Bit EFI ROM, which also boots the system to a 32-Bit Kernel, up until 10.7.5. Since my Mac Pro 2,1 is running Mac OS X 10.10.5 using a 32-Bit boot.efi file, yet, is booting into a 64-bit Kernel, it can fully address the 64 GB of RAM installed. These modules were purchased from eBay, and were all pulled from an HP Proliant server, and are of the Micron brand.
The sole purpose of this post is to prove a point, to serve as a valid testament to the "theory" which states these machines can "potentially" support 64 GB of RAM. I understand, these machines are no longer supported, and not a whole bunch of people actually own this particular machine anymore. If, however, it serves any informational reference, to, reinforce the decisions made by those willing to upgrade their machines, in such a way which confirms the ability to run 64 GB of RAM on a Mac Pro 2,1/1,1, then, this would be a strong reference point from which to confirm such possibilities. You're welcome.
Mac Pro, OS X Yosemite (10.10), x5365 x2, 32G R, 80G SSD/3T HDD GTX960