1. Disable all Extensions and test.
Safari > Preferences > Extensions
To uninstall an extension, select it and click the “Uninstall” button.
2. Safari > Preferences > Search > Search Engine :
Select your preferred search engine.
3. Safari > Preferences > General > Homepage:
Set your Homepage.
4. Use free Malwarebytes Anti-Malware for Mac/ AdwareMedic to remove adware
https://www.malwarebytes.org/antimalware/mac/
Download, install , open, and run it by clicking “Scan for Adware” button to remove adware.
Once done, quit Malwarebytes Anti-Malware.
or
Remove the adware manually by following the “HowTo” from Apple.
http://support.apple.com/en-us/HT203987
5. Hold the shift key down and launch Safari