Bose is really a lot of marketing hype. Before I got into music production I was into Hi-Fi home theater systems. While Bose makes a killing saying its sound "envelopes" you, in these "miraculously" tiny speakers, it's completely untrue. The drivers were pretty bad, and their $2000 systems would be on par with $300 systems by other brands.
When you're setting up a system, especially for mixing audio, you don't want "reflections" off walls. Professional studios spend thousands of dollars on construction and sound reinforcement to get rid of them. Ideally, you'd want a clear, precise, distinct sound, and reflections muddy up all of that up.
As for recommendations, the Blue Sky Media desk is nice. I demoed it before deciding on going with my Dynaudios, which were only a few hundred $ more.
Also, do you really need the subwoofer?
There are 2.0 systems out there that go really low. If you're used to small cones, like those commonly found on computer speakers (2-3") then that's where the subwoofer comes into play, but on 2.0 audio monitors, small drivers are at least 6", and 8" drivers are the same size as sufwoofer cones on computer systems. I mix on my Dynaudio BM5A's and I find it covers all but the very low subbasses very well.
Anyway, what is your primary use for these?
If you're looking to semi-seriously mix audio, then go with audio monitors. There are cheap options out there (KRK, M-Audio, Blue Sky, Behringer) that handle mixing and are 2.0 (usually cheaper than 2.1). I've personally found to prefer a good 2.0 setup over a 2.1 system.
If you're looking for something mainly to enjoy music and play games, then go with something like a Klipsch system. Probably cheaper overall and Klipsch makes fine systems.