Will Safari work with Windows 10?

No! Safari has been unsupported on any version of Windows for several years. It would be utterly insecure to use any version of Safari for Windows at this point in time.

In 2016, you have several very modern and secure browsers to choose from on Windows including Chrome, Firefox, and Edge (native browser of Windows 10).

Please don't be tempted to go searching download hosting sites for the now grossly outdated Safari for Windows. It has not been updated since May 2012 and is now a huge security risk. Also, many of those hosting sites that claim to give you a copy of Safari will also give you malware whether you want it or not. It's jut not worth it.