Greetings sawatchboy,
Thank you for using Apple Support Communities.
Based on your post, I see that your Epson scan application started crashing immediately when opening. You've spoken with Epson, and tested this issue in a new user account, and you are still having an issue. I can definitely understand how important it is that you are able to use your scanning software. I'm happy to assist you in resolving this issue.
You mentioned a possible conflict with another application. I would recommend starting your computer into safe mode, and then testing to see if you get the same result with the Epson app crashing. Safe mode (sometimes called safe boot) is a way to start up your Mac so that it performs certain checks, and prevents some software from automatically loading or opening.
Use OS X El Capitan: Start up in safe mode, specifically, this section:
Starting up in safe mode may help you diagnose problems you’re having with your Mac.
Important: To print these instructions, click the Share button
in the Help window, then choose Print.
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Choose Apple menu > Shut Down.
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After your Mac shuts down, wait 10 seconds, then press the power button.
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Immediately after you hear the startup tone, hold down the Shift key.
You should press the Shift key as soon as possible after you hear the startup tone, but not before.
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Release the Shift key when you see the gray Apple logo and progress indicator.
To leave safe mode, restart your Mac again, but don’t hold down any keys during startup.
If you notice that you aren't having an issue in safe mode, take a look at the section 'If an issue doesn't happen in safe mode' from the article below.
Try safe mode if your Mac doesn't finish starting up
Best Regards.