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Helpful answers
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Sep 8, 2016 9:48 AM in response to Mac_TAby lllaass,Yes you can with a PCIe card that accepts 2 1/2 inch drives.
However per
https://eshop.macsales.com/item/OWC/SSDACL6G.S/
You will not gain anything since the
- 2006-2007 Mac Pro. These models utilize PCIe 1.0 slot which cannot be configured (even with the Expansion Utility in OS X) to address Accelsior S as anything but as a first generation one-lane card. As a result, Accelsior S performance will be limited to 190-200MB/s data rates. If maximum data rate speedis desired, we recommend the installation of a 2.5" OWC Mercury SSD in an open Mac Pro drive bay.
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Sep 9, 2016 2:25 AM in response to Mac_TAby John Lockwood,In addition to Illaass' answer if you did have a newer classic Mac Pro with faster PCIe slots then yes it would be much faster. This is because the built-in drive bays on all classic Mac Pro models is only SATA II i.e. 3Gbps whereas a PCIe SATA adapter would be SATA III which is double the speed i.e. 6Gbps.
This speed difference does not help with traditional hard disks but does make a noticeable difference for SATA SSD drives. Of course as Illaass mentioned this will not help you currently.