ITunes can't connect after update to iOS10 - invalid response

Uninstall iTunes and Apple Mobile Device Support. Reinstall iTunes.

Do you have the latest itunes that was released on ios 10 launch day?

Did you uninstall iTunes and Apple Mobile Device Support? Or just update iTunes. If the device isn't recognized by iTunes it usually has something to do with that mobile device support software and reinstalling usually fixes it.

I'm having the same problem as well, but my message is slightly different. When I plug in my iPhone using the Apple USB, the pop up window says, "iTunes could not connect to the iPhone because an invalid response was received from the device."

I've read some of the responses below, and if I uninstall iTunes, will that not delete all of my music?

Please help and thank you in advance!

No, everything will stay, since those are files on your computer, once you reinstall iTunes it will ask you if you want to scan for files and it will get your music again.

Thanks for the response ChuckD09. Will hope that I have the same luck you did 🙂

So I reinstalled iTunes and still no go. Anytime I plug my phone into the computer, my phone gets a message asking if I trust this computer. I say "Trust" and my computer still says, "iTunes could not connect to the iPhone because an invalid response was received from the device." UGH!!! Where do I uninstall the Apple Mobile Device Support from?

Are you on Windows or Mac? If it is Windows you'll find that under the control panel>programs and features

On Mac you can't uninstall it

If you are using Windows, then follow turingtest2's procedure in the Removing and reinstalling iTunes and other software components section here:

Troubleshooting issues with iTunes for Windows updates

I'm on a Mac. I've uninstalled iTunes, uninstalled the Apple Mobile Device Support, reinstalled iTunes and reset all settings on my phone. Followed the instructions on this website to remove AMDS:

Finder > Applications and move the iTunes icon to the Trash. Select Go > Go to Folder and enter /System/Library/Extensions and click Go, find AppleMobileDevice.text and drag it into the Trash Bin. Again select Go > Go to Folder and enter /Library/Receipts/ and click Go and find AppleMobileDeviceSupport.pkg and move it to the Trash. Restart your computer. Empty your trash (Finder > Empty Trash) and restart your computer again. Now download and install the latest version of iTunes. If you see: “iTunes” can’t be modified or deleted because it’s required by Mac OS X.

Still can't connect to iTunes. Any other ideas?

What version of OS X?