There is no universal fix at this point. The problem primarily involves crashing to the login screen when going to fullscreen for apps, or video (including in iTunes), or animating between Spaces. There appear to be variations as well so we don't all have exactly the same problem.
A variety of fixes have worked for some people, some permanently and some temporarily.
Installing a program called Little Snitch permanently, so far (several weeks of heavy use), resolved the problem for me, due to something Little Snitch did during installation (not the program itself), though I don't know what that was. Several others have reported success with this, but many others have reported no success. I have worked with Apple Support on this issue for weeks, sending them multiple logs, and they do seem to acknowledge that this is an issue. I was promised a "hot fix" a few weeks ago but haven't seen anything yet. Perhaps it will be fixed in 10.12.1.
For people who've had the problem exclusively with Chrome, turning off hardware acceleration in Advanced Preferences seems to be a fix. It was first posted on Reddit.
DuetDisplay has known conflicts with MacOS Sierra. If you have DuetDisplay, which lets you use your iPad as a separate display, you may want to look into this.
I've also seen fixes posted that are related to Razer products and other third-party hardware and drivers as well. The problem does not, however, appear to be limited to a particular Mac—iMac vs MacBook vs. MacBook Pro—or configuration.
One of the things to try is to create a "test" admin account. If the problem does not occur in the "test" account, that would be consistent with others who have this problem; some have suggested migrating all of your stuff to the new account. This can be done, and is probably a true fix, but is no fun.
10.12.1 cannot be that far away. You may want to try to hold out a bit longer.