I'm use iPhone 6 (16GB) with iOS 10.0.1.
As I made the call with TTY Software under Phone app.
For more than 20 minutes, the conversation by incoming cause freeze for a second then resume. Then next incoming message, it freeze for 5 second then resume. Then another incoming, it freeze for 10 to 15 second. It keep go on as it reach minutes and more.
I think it had to do with memory not process well.