Q: safari Preferences Not Opening

1. Disable Extensions and test.

   Safari > Preferences > Extensions

   Select and disable all extensions and test.

   Enable Extensions one by one and test.

   To uninstall any extension, select it and click the “Uninstall” button.

2. Safari > Preferences > Search > Search engine:

     Select your preferred search engine

Might be a corrupt .plist.

Do a backup, preferably 2 backups on 2 separate drives.

Quit the application.

Go to Finder and select your user/home folder. With that Finder window as the front window, either select Finder/View/Show View options or go command - J.  When the View options opens, check ’Show Library Folder’. That should make your user library folder visible in your user/home folder.  Select Library. Then go to Preferences/com.apple.Safari.plist.  Move the .plist to your desktop.

Restart the computer, open the application, and test. If it works okay, delete the plist from the desktop.

If the application is the same, return the .plist to where you got it from, overwriting the newer one.

Try a restart.

Do a backup, using either Time Machine or a cloning program, to ensure files/data can be recovered. Two backups are better than one.

Try setting up another admin user account to see if the same problem continues. If Back-to-My Mac is selected in System Preferenes, the Guest account will not work. The intent is to see if it is specific to one account or a system wide problem. This account can be deleted later.

Isolating an issue by using another user account

If the problem is still there, try booting into the Safe Mode using your normal account.  Disconnect all peripherals except those needed for the test. Shut down the computer and then power it back up after waiting 10 seconds. Immediately after hearing the startup chime, hold down the shift key and continue to hold it until the gray Apple icon and a progress bar appear. The boot up is significantly slower than normal. This will reset some caches, forces a directory check, and disables all startup and login items, among other things. When you reboot normally, the initial reboot may be slower than normal. If the system operates normally, there may be 3rd party applications which are causing a problem. Try deleting/disabling the third party applications after a restart by using the application un-installer or by using the developer’s uninstall instructions. For each disable/delete, you will need to restart if you don't do them all at once.

Safe Mode - About

Safe Mode - Yosemite

If it works in the Safe Mode, try running this program when booted normally and then copy and paste the output in a reply. The program was created by Etresoft, a frequent contributor.  Please use copy and paste as screen shots can be hard to read. On the screen with Options, please open Options and check the bottom 2 boxes before running. Click “Share Report” button in the toolbar, select “Copy to Clipboard” and then paste into a reply. This will show what is running on your computer. No personal information is shown.
  

Etrecheck – System Information

1.  Visit the site you want it be the Home page.

     Safari > Preferences > General >  Homepage

     Click the button “Set to Current Page” button.

2.  If this does’t help:

    Use  Malwarebytes Anti-Malware for Mac to remove adware.

     https://www.malwarebytes.org/antimalware/mac/

   Download, install , open,  and run it by clicking “Scan for Adware” button   to remove adware.

   Once done, quit Malwarebytes Anti-Malware.

Do a backup, preferable 2 separate ones on 2 drives. Boot to the Recovery Volume (command - R on a restart or hold down the option/alt key during a restart and select Recovery Volume). Run Disk Utility Verify/Repair Disk and Repair Permissions until you get no errors. Then re-install the OS.

OS X Recovery

OS X Recovery (2)