Macbook Pro performance awful

My MacBook performance has been slowing for some time, but has seriously declined following Sierra update. I have run EtreCheck and would really appreciate some help interpreting the results.

Thanks

EtreCheck version: 3.0.6 (315)

Report generated 2016-10-14 21:51:02

Download EtreCheck from https://etrecheck.com

Runtime 12:07

Performance: Poor

Click the [Support] links for help with non-Apple products.

Click the [Details] links for more information about that line.

Problem: Computer is too slow

Hardware Information:ⓘ

MacBook Pro (13-inch, Early 2011)

[Technical Specifications] - [User Guide] - [Warranty & Service]

MacBook Pro - model: MacBookPro8,1

1 2.3 GHz Intel Core i5 CPU: 2-core

4 GB RAM Upgradeable - [Instructions]

BANK 0/DIMM0

2 GB DDR3 1333 MHz ok

BANK 1/DIMM0

2 GB DDR3 1333 MHz ok

Bluetooth: Old - Handoff/Airdrop2 not supported

Wireless: en1: 802.11 a/b/g/n

Battery: Health = Normal - Cycle count = 986

Video Information:ⓘ

Intel HD Graphics 3000

Color LCD 1280 x 800

System Software:ⓘ

macOS Sierra 10.12 (16A323) - Time since boot: about one hour

Disk Information:ⓘ

Hitachi HTS545032B9A302 disk0 : (320.07 GB) (Rotational)

EFI (disk0s1) <not mounted> : 210 MB

Recovery HD (disk0s3) <not mounted> [Recovery]: 650 MB

Macintosh HD (disk1) / [Startup]: 318.84 GB (64.42 GB free)

Core Storage: disk0s2 319.21 GB Online

MATSHITADVD-R UJ-898 ()

USB Information:ⓘ

Apple Inc. FaceTime HD Camera (Built-in)

Apple Inc. Apple Internal Keyboard / Trackpad

Apple Inc. BRCM2070 Hub

Apple Inc. Bluetooth USB Host Controller

Apple Computer, Inc. IR Receiver

Thunderbolt Information:ⓘ

Apple Inc. thunderbolt_bus

Gatekeeper:ⓘ

Mac App Store and identified developers

Kernel Extensions:ⓘ

/Library/Extensions

[not loaded] com.citrix.kext.gusb (1.0 - 2016-10-13) [Support]

System Launch Agents:ⓘ

[not loaded] 8 Apple tasks

[loaded] 165 Apple tasks

[running] 71 Apple tasks

[killed] 27 Apple tasks

27 processes killed due to insufficient RAM

System Launch Daemons:ⓘ

[not loaded] 38 Apple tasks

[loaded] 160 Apple tasks

[running] 90 Apple tasks

[killed] 16 Apple tasks

16 processes killed due to insufficient RAM

Launch Agents:ⓘ

[loaded] com.citrix.AuthManager_Mac.plist (2016-01-26) [Support]

[running] com.citrix.ReceiverHelper.plist (2016-01-26) [Support]

[running] com.citrix.ServiceRecords.plist (2016-01-26) [Support]

[running] com.kodak.BonjourAgent.plist (2012-09-21) [Support]

Launch Daemons:ⓘ

[loaded] com.adobe.fpsaud.plist (2016-09-24) [Support]

[loaded] com.apple.installer.osmessagetracing.plist (2016-09-13)

User Launch Agents:ⓘ

[loaded] com.adobe.ARM.[...].plist (2014-07-13) [Support]

[failed] com.apple.CSConfigDotMacCert-[...]@me.com-SharedServices.Agent.plist (2011-03-05)

[loaded] com.kodak.KODAK AiO Annual Opt.plist (2015-11-23) [Support]

[loaded] com.kodak.KODAK AiO Firmware Updater.plist (2016-10-13) [Support]

[loaded] com.kodak.KODAK AiO Software Updater.plist (2016-10-11) [Support]

[running] com.kodak.StatisticCollection.plist (2015-11-23) [Support]

[running] com.spotify.webhelper.plist (2016-10-14) [Support]

User Login Items:ⓘ

Safari Application (/Applications/Safari.app)

Dropbox Application (/Incompatible Software/Dropbox.app)

AdobeResourceSynchronizer Application (/Applications/Adobe Reader.app/Contents/Support/AdobeResourceSynchronizer.app)

Spotify Application Hidden (/Applications/Spotify.app)

Internet Plug-ins:ⓘ

Flip4Mac WMV Plugin: 2.3.0.14 (2011-03-05) [Support]

FlashPlayer-10.6: 23.0.0.185 - SDK 10.9 (2016-10-12) [Support]

QuickTime Plugin: 7.7.3 (2016-09-14)

AdobePDFViewerNPAPI: 11.0.12 - SDK 10.6 (2015-09-27) [Support]

AdobePDFViewer: 11.0.12 - SDK 10.6 (2015-09-27) [Support]

Flash Player: 23.0.0.185 - SDK 10.9 (2016-10-12) [Support]

CitrixICAClientPlugIn: 12.1.100 - SDK 10.10 (2016-01-26) [Support]

OfficeLiveBrowserPlugin: 12.3.6 (2013-03-23) [Support]

Silverlight: 5.1.41212.0 - SDK 10.6 (2016-06-04) [Support]

iPhotoPhotocast: 7.0 - SDK 10.7 (2012-03-29)

User internet Plug-ins:ⓘ

Google Earth Web Plug-in: 7.1 (2013-10-07) [Support]

3rd Party Preference Panes:ⓘ

Flash Player (2016-09-24) [Support]

Flip4Mac WMV (2011-03-05) [Support]

Time Machine:ⓘ

Mobile backups: ON

Auto backup: YES

Volumes being backed up:

Macintosh HD: Disk size: 318.84 GB Disk used: 254.42 GB

Destinations:

LaCie [Local]

Total size: 2.00 TB

Total number of backups: 41

Oldest backup: 25/09/2011, 14:06

Last backup: 20/08/2016, 16:46

Size of backup disk: Excellent

Backup size 2.00 TB > (Disk size 318.84 GB X 3)

Top Processes by CPU:ⓘ

8% mds_stores

7% WindowServer

3% mds

2% AdobeReader(2)

2% kernel_task

Top Processes by Memory:ⓘ

536 MB kernel_task

156 MB mds_stores

152 MB com.apple.WebKit.WebContent(4)

98 MB Safari

94 MB Mail

Virtual Memory Information:ⓘ

439 MB Free RAM

3.57 GB Used RAM (732 MB Cached)

22 MB Swap Used

Diagnostics Information:ⓘ

Oct 14, 2016, 08:11:58 PM ~/Library/Logs/DiagnosticReports/quicklookd_2016-10-14-201158_[redacted].crash

/System/Library/Frameworks/QuickLook.framework/Versions/A/Resources/quicklookd. app/Contents/MacOS/quicklookd

Oct 14, 2016, 08:11:33 PM ~/Library/Logs/DiagnosticReports/quicklookd_2016-10-14-201133_[redacted].crash

Oct 14, 2016, 08:10:58 PM /Library/Logs/DiagnosticReports/suggestd_2016-10-14-201058_[redacted].cpu_resou rce.diag [Details]

suggestd

Oct 14, 2016, 07:58:58 PM Self test - passed

Oct 13, 2016, 10:45:05 PM /Library/Logs/DiagnosticReports/OtherUsersExtension_2016-10-13-224505_[redacted ].cpu_resource.diag [Details]

/System/Library/PrivateFrameworks/StorageManagement.framework/PlugIns/OtherUser sExtension.appex/Contents/MacOS/OtherUsersExtension

Oct 13, 2016, 05:38:08 PM ~/Library/Logs/DiagnosticReports/iTunes_2016-10-13-173808_[redacted].crash

/Applications/iTunes.app/Contents/MacOS/iTunes

Oct 12, 2016, 09:17:14 PM ~/Library/Logs/DiagnosticReports/Mail_2016-10-12-211714_[redacted].crash

/Applications/Mail.app/Contents/MacOS/Mail