It might work, in that the touchscreen might send compatible trackpad-like signals and gestures to the Mac, but you'd have to confirm that it could work at that level.
The big, big problem is even if you can get the touchscreen to work, macOS itself is fundamentally not prepared for touchscreens as well as say Windows 10 is. There are far too many controls in macOS that are sized for a precise mouse pointer, which would be agonizing to try and hit with a big fat finger. Windows 10 has a complete touch version of the user interface that provides big finger-friendly controls. That is completely missing from macOS, so even if you connect a touchscreen to the Mac, macOS is not ready for it.
Is there any chance your Mom could do well with an iPad or iPad Pro? The iPad Pro screen is as big as a computer, and when you attach a keyboard cover it's a lot like a touchscreen laptop, and as you know, the design and operation of iOS is fully touch-based. Is there anything she really needs a computer for, or would an iPad do everything she needs?
If she insists on a real computer (not iPad) that has a real touchscreen, it's not going to be a Mac.