iTunes 12.5.4.42 Won't Save Setup Settings

It used to be that resetting preferences by deleting a file called C:\Users\<User>\AppData\Roaming\Apple Computer\iTunesiTunesPrefs.xml would resolve this sort of problem. However a recent build of iTunes changed the way preferences are stored. Here is a list of the items that I noticed changing a few weeks ago each time I updated something in preferences. Can you see each of these three listed folders inside %appdata%\Apple Computer? If not the permissions for the folders might be wrong. You could try deleting them so they are rebuilt as needed, or create them manually if you don't see them.

• C:\Users\<User>\AppData\Roaming\Apple Computer\iTunes\Cookies
• C:\Users\<User>\AppData\Roaming\Apple Computer\Preferences
• C:\Users\<User>\AppData\Roaming\Apple Computer\Preferences\By Host

It may also help to right-click the icon that launches iTunes and use Run as administrator or open it once in safe mode by holding down ctrl+shift as you launch it.

If nothing so far has helped see Fix unexpected quits or launch issues in iTunes for Windows - Apple Support and test behaviour in a new user account.

tt2

Right-click the iTunes icon in your start menu and click Run as administrator then immediately hold down Ctrl+Shift and continue to hold until you get a prompt about launching iTunes in Safe Mode, click Continue, change some settings, close and then reopen to see if the settings now persist.

tt2

I cannot think of any new insight that I've had into this issue.

Is the file com.apple.iTunes.plist file being made/updated in the Preferences folder?

Have you tested the behaviour in a different user profile?

What anti-virus software do you have?

tt2