Solution for error "Creating file: 1008:5, -5000 Access Denied Error":
Note: The following example uses the FireFox browser application path.
Open the Terminal application (in the Applications > Utilities folder) and type the following text:
sudo chmod 777 /Applications/Firefox.app/Contents/MacOS/components/
Enter the password for the ROOT user.
Reinstall Flash Player 9.
It may be necessary to run sudo chmod on each browser application path for which you'd like to install Flash Player.
http://www.adobe.com/cfusion/knowledgebase/index.cfm?id=4aa64290