Wake up problem mac mini 2012

After upgrading to 10.12.5 (it still exists using 10.12.6) my mac mini will not wake up from sleeping mode.

I can see from the small led it powers up but my screen stays black or sometimes my mac has lost its startup disk (blinking question mark/folder icon).

I have already reset the PRAM, I restored the system (using Command+R) after rebooting and I used the 10.2.6 combo update but nothing helped.

EtreCheck version: 3.4.2 (436) Report generated 2017-08-20 06:51:38 Download EtreCheck from https://etrecheck.com Runtime: 2:09 Performance: Excellent Click the [Lookup] links for more information from Apple Support Communities. Click the [Details] links for more information about that line. Problem: Other problem Description: Wakeup problem Hardware Information: &#9432; Mac mini (Late 2012) [Technical Specifications] - [User Guide] - [Warranty & Service] Mac mini - model: Macmini6,1 1 2,5 GHz Intel Core i5 (i5-3210M) CPU: 2-core 16 GB RAM Upgradeable - [Instructions] BANK 0/DIMM0 8 GB DDR3 1600 MHz ok BANK 1/DIMM0 8 GB DDR3 1600 MHz ok Bluetooth: Good - Handoff/Airdrop2 supported Wireless: en1: Unknown Video Information: &#9432; Intel HD Graphics 4000 - VRAM: 1536 MB DELL U2415 1920 x 1200 @ 60 Hz Disk Information: &#9432; KINGSTON SH103S3480G disk0: (480,1 GB) (Solid State - TRIM: No) [Show SMART report] EFI (disk0s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB [redacted] (disk0s2 - Journaled HFS+) / [Startup]: 479.24 GB (98.47 GB free) Recovery HD (disk0s3 - Journaled HFS+) <not mounted> [Recovery]: 650 MB USB Information: &#9432; USB20Bus hub_device hub_device Apple, Inc. IR Receiver Apple Inc. BRCM20702 Hub Apple Inc. Bluetooth USB Host Controller USB20Bus hub_device Apple, Inc. Keyboard Hub Mitsumi Electric Apple Optical USB Mouse Apple, Inc Apple Keyboard USB30Bus Thunderbolt Information: &#9432; Apple Inc. thunderbolt_bus System Software: &#9432; macOS Sierra 10.12.6 (16G29) - Time since boot: less than an hour Gatekeeper: &#9432; Mac App Store and identified developers Kernel Extensions: &#9432; /Applications/Toast 14 Titanium/Toast Titanium.app [not loaded] com.roxio.TDIXController (2.0) [Lookup] /Library/Extensions [loaded] at.obdev.nke.LittleSnitch (3.7.3 - SDK 10.11) [Lookup] [loaded] com.malwarebytes.mbam.rtprotection (3.0 - SDK 10.12) [Lookup] /System/Library/Extensions [loaded] com.Cycling74.driver.Soundflower (1.6.7 - SDK 10.7) [Lookup] [not loaded] com.tomtom.driver.UsbEthernetGadget (1.0.0d1) [Lookup] System Launch Agents: &#9432; [not loaded] 7 Apple tasks [loaded] 182 Apple tasks [running] 93 Apple tasks System Launch Daemons: &#9432; [not loaded] 42 Apple tasks [loaded] 180 Apple tasks [running] 96 Apple tasks Launch Agents: &#9432; [running] at.obdev.LittleSnitchUIAgent.plist (Objective Development Software GmbH - installed 2017-02-19) [Lookup] [not loaded] com.adobe.AAM.Updater-1.0.plist (Adobe Systems, Inc. - installed 2017-08-10) [Lookup] [running] com.malwarebytes.mbam.frontend.agent.plist (? 631295be 680057a5 - installed 2017-08-16) [Lookup] [loaded] com.oracle.java.Java-Updater.plist (? abc7194a 72ac4dde - installed 2017-08-19) [Lookup] [not loaded] com.teamviewer.teamviewer.plist (TeamViewer GmbH - installed 2017-08-15) [Lookup] [not loaded] com.teamviewer.teamviewer_desktop.plist (TeamViewer GmbH - installed 2017-07-27) [Lookup] Launch Daemons: &#9432; [running] at.obdev.littlesnitchd.plist (Objective Development Software GmbH - installed 2017-02-19) [Lookup] [loaded] com.adobe.SwitchBoard.plist (? 856489a3 0 - installed 2015-02-06) [Lookup] [loaded] com.adobe.agsservice.plist (Adobe Systems, Inc. - installed 2016-04-20) [Lookup] [loaded] com.adobe.fpsaud.plist (? 2afb3af7 18a4fa69 - installed 2017-06-23) [Lookup] [loaded] com.malwarebytes.HelperTool.plist (Malwarebytes Corporation - installed 2017-02-08) [Lookup] [running] com.malwarebytes.mbam.rtprotection.daemon.plist (? 31419c10 e3f423ee - installed 2017-08-16) [Lookup] [running] com.malwarebytes.mbam.settings.daemon.plist (? a40d558f d0b9e521 - installed 2017-08-16) [Lookup] [loaded] com.microsoft.autoupdate.helper.plist (Microsoft Corporation - installed 2017-08-13) [Lookup] [loaded] com.microsoft.office.licensing.helper.plist (? 6d8cb30e 8b29c3ef - installed 2012-04-02) [Lookup] [loaded] com.oracle.java.Helper-Tool.plist (Shell Script e3fefdd2 - installed 2017-07-22) [Lookup] [loaded] com.rogueamoeba.instanton-agent.plist (Rogue Amoeba Software, LLC - installed 2015-07-31) [Lookup] [loaded] com.teamviewer.Helper.plist (TeamViewer GmbH - installed 2017-07-27) [Lookup] [not loaded] com.teamviewer.teamviewer_service.plist (TeamViewer GmbH - installed 2017-08-15) [Lookup] User Launch Agents: &#9432; [loaded] com.adobe.AAM.Updater-1.0.plist (Adobe Systems, Inc. - installed 2017-08-10) [Lookup] [loaded] com.adobe.ARM.[...].plist (? 881a4a1c f027a735 - installed 2017-08-10) [Lookup] User Login Items: &#9432; MenuMetersApp Application (/Library/PreferencePanes/MenuMeters.prefPane/Contents/Resources/MenuMetersApp.a pp) ClamXav Sentry Application (/Applications/ClamXav.app/Contents/Resources/ClamXav Sentry.app) Internet Plug-ins: &#9432; AdobeExManDetect: AdobeExManDetect 1.1.0.0 (installed 2015-02-06) [Lookup] FlashPlayer-10.6: 26.0.0.137 (installed 2017-07-13) [Lookup] QuickTime Plugin: 7.7.3 (installed 2017-08-19) AdobePDFViewerNPAPI: 11.0.21 (installed 2017-08-10) [Lookup] AdobePDFViewer: 11.0.21 (installed 2017-08-10) [Lookup] Flash Player: 26.0.0.137 (installed 2017-07-13) Outdated! Update SharePointBrowserPlugin: 14.7.6 (installed 2017-08-13) [Lookup] JavaAppletPlugin: Java 8 Update 144 build 01 (installed 2017-08-19) Check version Safari Extensions: &#9432; [enabled] AdBlock - BetaFish, Inc. - https://getadblock.com (installed 2015-01-24) [not loaded] ClickToPlugin - Marc Hoyois - http://hoyois.github.com/safariextensions/clicktoplugin/ (installed 2014-12-08) [enabled] Ghostery - GHOSTERY, Inc. - https://www.ghostery.com/ (installed 2016-03-14) Time Machine: &#9432; Time Machine not configured! Top Processes by CPU: &#9432; 28% com.apple.WebKit.WebContent 11% Safari 8% WindowServer 4% kernel_task 3% com.apple.WebKit.Networking Top Processes by Memory: &#9432; 918 MB kernel_task 511 MB clamd 352 MB Safari 201 MB mds_stores 194 MB com.apple.WebKit.WebContent Top Processes by Network Use: &#9432; Input Output Process name 1 MB 65 KB com.apple.WebKit.Networking 34 KB 4 KB mDNSResponder 9 KB 6 KB apsd 576 B 576 B ntpd 522 B 354 B netbiosd Top Processes by Energy Use: &#9432; 9.58 WindowServer 5.94 Safari 4.92 com.apple.WebKit.WebContent 2.68 MenuMetersApp Virtual Memory Information: &#9432; 12.21 GB Available RAM 9.17 GB Free RAM 3.79 GB Used RAM 3.04 GB Cached files 0 B Swap Used Diagnostics Information: &#9432; 2017-08-20 06:37:50 Last shutdown cause: 3 - Hard shutdown 2017-08-19 10:05:43 com.apple.WebKit.WebContent High CPU use [Open] [Details]

So I always have to do a hard shutdown and reboot. I hope somebody can give me more tips to solve this problem.