The shortcut didn't work in Safe Mode, so I ran Etrecheck. The results are shown below. I hope this info helps.
EtreCheck version: 3.4.4 (448)
Report generated 2017-09-19 19:02:48
Download EtreCheck from https://etrecheck.com
Runtime: 1:45
Performance: Excellent
Click the [Lookup] links for more information from Apple Support Communities.
Click the [Details] links for more information about that line.
Problem: Other problem
Description:
Hot corners function for starting screen saver does not work for any user account.
Hardware Information:ⓘ
MacBook Air (13-inch, Early 2014)
[Technical Specifications] - [User Guide] - [Warranty & Service]
MacBook Air - model: MacBookAir6,2
1 1.4 GHz Intel Core i5 (i5-4260U) CPU: 2-core
4 GB RAM Not upgradeable
BANK 0/DIMM0
2 GB DDR3 1600 MHz ok
BANK 1/DIMM0
2 GB DDR3 1600 MHz ok
Handoff/Airdrop2: supported
Wireless: en0: Unknown
Battery: Health = Normal - Cycle count = 12
Video Information:ⓘ
Intel HD Graphics 5000 - VRAM: 1536 MB
Color LCD 1280 x 800
Disk Information:ⓘ
APPLE SSD SM0256F disk0: (251 GB) (Solid State - TRIM: Yes)
[Show SMART report]
EFI (disk0s1 - MS-DOS FAT32) <not mounted> [EFI]: 210 MB
(disk0s2) <not mounted> [CoreStorage Container]: 250.14 GB
Recovery HD (disk0s3 - Journaled HFS+) <not mounted> [Recovery]: 650 MB
USB Information:ⓘ
USB30Bus
Apple Inc. BRCM20702 Hub
Apple Inc. Bluetooth USB Host Controller
Thunderbolt Information:ⓘ
Apple Inc. thunderbolt_bus
Apple Inc. Thunderbolt to Gigabit Ethernet Adapter
Virtual disks:ⓘ
Macintosh HD (disk1 - Journaled HFS+) / [Startup]: 249.82 GB (222.69 GB free)
Physical disk: disk0s2 250.14 GB Online
System Software:ⓘ
macOS Sierra 10.12.6 (16G29) - Time since boot: less than an hour
Gatekeeper:ⓘ
Mac App Store and identified developers
System Launch Agents:ⓘ
[not loaded] 7 Apple tasks
[loaded] 189 Apple tasks
[running] 89 Apple tasks
System Launch Daemons:ⓘ
[failed] com.apple.watchdogd.plist (Apple, Inc. - installed 2017-07-15)
[not loaded] 42 Apple tasks
[loaded] 183 Apple tasks
[running] 92 Apple tasks
Launch Agents:ⓘ
[not loaded] com.adobe.ARMDCHelper.cc24aef4a1b90ed56a725c38014c95072f92651fb65e1bf9c8e43c37a2 3d420d.plist (Adobe Systems, Inc. - installed 2017-01-10) [Lookup]
[not loaded] com.brother.LOGINserver.plist (? a1772de2 41ad4933 - installed 2016-09-21) [Lookup]
[not loaded] com.oracle.java.Java-Updater.plist (? 6647bcbe 72ac4dde - installed 2017-08-29) [Lookup]
Launch Daemons:ⓘ
[not loaded] com.adobe.ARMDC.Communicator.plist (Adobe Systems, Inc. - installed 2017-01-10) [Lookup]
[not loaded] com.adobe.ARMDC.SMJobBlessHelper.plist (Adobe Systems, Inc. - installed 2017-01-10) [Lookup]
[not loaded] com.adobe.fpsaud.plist (? 2afb3af7 eb6bee8f - installed 2017-08-29) [Lookup]
[not loaded] com.malwarebytes.HelperTool.plist (Malwarebytes Corporation - installed 2017-02-11) [Lookup]
[not loaded] com.oracle.java.Helper-Tool.plist (Shell Script e3fefdd2 - installed 2017-07-22) [Lookup]
User Login Items:ⓘ
iTunesHelper Application (Apple, Inc. - installed 2017-09-15)
(/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
Internet Plug-ins:ⓘ
FlashPlayer-10.6: 27.0.0.130 (installed 2017-09-13) [Lookup]
QuickTime Plugin: 7.7.3 (installed 2017-08-15)
AdobePDFViewerNPAPI: 15.010.20060 (installed 2016-02-26) [Lookup]
AdobePDFViewer: 15.010.20060 (installed 2016-02-26) [Lookup]
Flash Player: 27.0.0.130 (installed 2017-09-13) [Lookup]
PepperFlashPlayer: 27.0.0.130 (installed 2017-09-14) [Lookup]
JavaAppletPlugin: Java 8 Update 144 build 01 (installed 2017-08-29) Check version
3rd Party Preference Panes:ⓘ
Flash Player (installed 2017-08-29) [Lookup]
Java (installed 2017-08-29) [Lookup]
Time Machine:ⓘ
Time Machine not configured!
Top Processes by CPU:ⓘ
1% WindowServer
1% fontd
0% launchd
0% syslogd
0% kernel_task
Top Processes by Memory:ⓘ
401 MB kernel_task
137 MB Safari
109 MB com.apple.WebKit.WebContent
98 MB icdd
88 MB assistantd
Top Processes by Network Use:ⓘ
Input Output Process name
10 KB 7 KB mDNSResponder
9 KB 6 KB apsd
1 KB 762 B netbiosd
288 B 288 B ntpd
Top Processes by Energy Use:ⓘ
2.44 WindowServer
0.02 opendirectoryd
0.02 symptomsd
0.02 launchd
Virtual Memory Information:ⓘ
2.21 GB Available RAM
941 MB Free RAM
1.79 GB Used RAM
1.29 GB Cached files
0 B Swap Used
Software installs:ⓘ
Java 8 Update 144: (installed 2017-08-29)
Adobe Flash Player: (installed 2017-09-13)
Adobe Pepper Flash Player: (installed 2017-09-14)
Radio FM: 1.1 (installed 2017-09-17)
Install information may not be complete.
Diagnostics Information:ⓘ
2017-09-17 16:03:31 iTunes.app High CPU use [Open] [Details]