Hopefully 10.13.1 will fix things as I'm having the same issue.
On my system (2012 MacBook Pro Retina 8Gb) it gets to the point where the mouse starts to glitch and the whole system freezes. Safari is one of the main culprits, though many other apps do it as well. For my case, I used an external monitor (4K Dell with the macbook cover down) as well as trying scaled and un-scaled resolutions without having an external monitor present.
Using the 4K monitor, the issue takes about 4-6 hours to reach a "critical" state, where the whole system freezes until windowserver is restarted. Using a "more space" scaled resolution, it takes roughy 12-18 hours and using the default resolution requires a daily or every-other-day restart. So it's clear that the issue worsens with resolution increase, but all tested resolutions do show the issue, at least in my case.
I've seen the issue from day 2 after installing High Sierra and tried safe-mode boots, SMC and PRAM resets and even re-installed the whole OS to make sure it wasn't an in-proper install or 3rd party software.