iTunes WILL NOT OPEN

I've tried everything I can think of besides a complete system reinstall. Since the past few security updates it just hangs on open.

Yes, this is an older machine. But it's otherwise in awesome shape. And my family uses it primarily as a media server…so the fact that iTunes isn't working anymore is, well, a big bummer.

Interestingly iTunes DOES open when I start my computer in safe mode. But it DOES NOT open when I try and launch iTunes in "iTunes Safe Mode." Which is kinda weird. Not sure the difference there.

I've tried deleting all the iTunes prefs. I've turned off all my login items. I've even reinstalled iTunes. But nothing works.

I have dozens of crash reports, system files, and even process samples…but it's a bit beyond my knowledge to read those and try and figure out WHAT is causing the hang.

Any ideas?