I'm not sure exactly how non responsive your environment is but with my 10.13.2 update;
After a reboot a day later I could hardly drag the curser around, bunch of beach balls. Apps that use to open on 10.13.1 no longer worked or would even load.
This is what worked for me;
Ran Maintenance scripts in terminal; sudo periodic daily weekly monthly
Opened a folder in finder and when down the list on the left for directories and opened each up until the icons appeared (because they were blank before.)
I went down every one and even added to the list on the left until they would load reasonably fast.
I did the same in SPOTLIGHT
I kept playing with spotlight although it was already indexed the results at first were not there or severely slow, so I kept playing with it and different terms until the results were reasonably fast.
After everything appeared back to normal I began normal operation loads and have not had any issues since.