Intentionally postponing installing High Sierra

My iMac IS compatible with OSX High Sierra, BUT I have intentionally postponed upgrading from Sierra to High Sierra because one very important database app I use is not yet compatible.

My question, should I go ahead and install other "updates" that are now available, or are most of those "updates" intended to work when High Sierra is running.

Is there any harm in installing updates while I'm still running OS 10.12.6?