In addition to what has been said here, I've seen some cases where AnySearch has triggered an odd bug in Safari. In cases where adware has changed the home page setting, that can leave you stuck with an inappropriate home page, even after all the adware has been removed, with seemingly no way to fix it.
The following procedure appears to solve the problem:
* In Safari, choose Preferences from the Safari menu.
* In the window that opens, click the General icon (if necessary)
* Enter your desired home page in the "Homepage" field, but DO NOT press return!
* At the top of the window, click any of the other icons (eg, Tabs, AutoFill, etc).
* You may see a prompt asking for confirmation for changing the home page. If so, confirm.
* Switch back to the General page and check to make sure the home page has been changed.