Safari will not launch on my MacBook Pro.

Try setting up another admin user account to see if the same problem continues. If Back-to-My Mac is selected in System Preferences, the Guest account will not work. The intent is to see if it is specific to one account or a system wide problem. This account can be deleted later. Please post if this worked or not.

Isolating an issue by using another user account

If the problem is still there, try booting into the Safe Mode using your normal account. Disconnect all peripherals except those needed for the test. Shut down the computer and then power it back up after waiting 10 seconds. Immediately after hearing the startup chime, hold down the shift key and continue to hold it until the gray Apple icon and a progress bar appear. The boot up is significantly slower than normal. This will reset some caches, forces a directory check, and disables all startup and login items, among other things. When you reboot normally, the initial reboot may be slower than normal. If the system operates normally, there may be 3rd party applications which are causing a problem. Try deleting/disabling the third party applications after a restart by using the application un-installer or by using the developer’s uninstall instructions. For each disable/delete, you will need to restart if you don't do them all at once. Please post if this worked or not.

Safe Mode - About El Capitan
also Sierra

Safe Mode Startup – El Capitan. also Sierra

If it works in the Safe Mode, try running this program when booted normally and then copy and paste the output in a reply. The program was created by Etresoft, a frequent contributor. Please use copy and paste as screen shots can be hard to read. Click “Share Report” button in the toolbar, select “Copy to Clipboard” and then paste into a reply. This will show what is running on your computer. No personal information is shown. You can run the report for free at least once, but if you run it several times, at some point it will ask you to pay a license fee.

Etrecheck – System Information

Install El Capitan or Later from Scratch

If possible backup your files.

1. Restart the computer. Immediately after the chime hold down the CommandandRkeys until the Apple logo appears. When the Utility Menu appears:
2. Select Disk Utility from the Utility Menu and click on Continue button.
3. When Disk Utility loads select the volume (indented entry, usually Macintosh HD) from the Device list.
4. Click on the Erase icon in Disk Utility's main window. A panel will drop down.
5. Set the Format type to APFS (SSDs only) or Mac OS Extended (Journaled.)
6. Click on the Apply button, then wait for the Done button to activate and click on it.
7. Quit Disk Utility and return to the Utility Menu.
8. Select Install OS X and click on the Continue button.

This will install the version of OS X you had installed.