Is this happening when using Safari or does it appear all the time?
Popup remover – Scam Zapper
If the pop-up reloads, force quit Safari (command - option/alt - esc) and reopen with the shift key held down. If that doesn't work, disconnect from the Internet, go to Safari/History and delete the website. Quit and reopen with the shift key held down. Then reconnect to the Internet.
Try running this program in your normal user account, then copy and paste the output in a reply. The program was created by etresoft, a frequent contributor. Please use copy and paste as screen shots can be hard to read. Click “Share Report” button in the toolbar, select “Copy Report” and then paste into a reply. This will show what is running on your computer. No personal information is shown. You can run the report for free at least once, but if you run it several times, at some point it will ask you to pay a license fee.