You’re welcome.
What determines the update of a "Smart Mailbox"?
Do I need to click away and click back?
Yes, you must do something like that for messages to disappear from the smart mailbox after reading them, but you don’t have to click on another mailbox if you don’t want to. You can just Command-click (⌘-click) on the smart mailbox to unselect it, then click on it again.
Note also that newly arrived messages will show up in the smart mailbox automatically without you having to do anything.
how do you suggest I indicate that I've completed/resolved
an email/TODO item?
Well, I guess you’ll have to change habits and decide
for each message whether you want to keep it or not. If you want to keep it, either do nothing if it’s already in the appropriate mailbox, or manually move it to the appropriate mailbox if it isn’t.
It may take some time getting used to it and you may end up accidentally deleting some messages, so make sure you choose the right
Preferences > Accounts > Mailbox Behaviors > Trash settings... 🙂