No. Nothing can. Malware is evolving and changing faster than any tool can adapt, meaning some attacks will get past any tool. And the attackers have tools that vary the attacks for each campaign. That is, the malware shipped out is unique, and the same executables are not used again.
There is nothing that can or will prevent a user from installing or invoking sketchy software (other than the user), or downloading a sketchy updater, or invoking an Office macro with malware, and the available AV tools can—at best—flag the worst of the dreck, while also providing a false perception of invulnerability.
The in-built AV software—Xprotect—does an adequate job at detecting and removing the most common Mac malware.
Most adware and other sortss of dreck that’s around for macOS is usually intentionally installed by the user, though. Usually as part of some other package, or by folks that intentionally spoof legitimate software packages, by folks with those “malware detectedl pop-ups, or folks themselves looking for and installing cracked apps or ilk.
Before you decide to add software—anti-malware tools are all nearly indistinguishable from malware in the way those tie into the operating system (and various AV tools are sources for instability, crashes and misbehaviour)—ask yourself if you have on-site and rotating off-site backups running, and if all your systems are on current versions, and if all your (for instance) network-connected printers are running current firmware. Because it’s these efforts that provide you with a defense, and with a path to recovery should the on-going efforts to breach your systems be successful.
Good or bad as some anti-malware tools might be, there is no magic solution here. It’s all work, and it’s all paying attention, thinking about what your particular environment and requirements might be. And it’s particularly having a (preferably occasionally tested) backup strategy.
