Remove Setapp application is not possible.

There's nothing in that list that is worth a darn. If you're worried about adware or malware then try Malwarebytes. It was developed by one of the top contributors to these forums and is excellent. You can run the free version of it (does not run automatically in the background).

Another excellent piece of software is Etrecheck. Etrecheck is a diagnostic tool that was developed by another one of the most respected users here in the ASC and recommended by Apple Support to provide a snapshot of the system and help identify the more obvious culprits that can adversely affect a Mac's performance.

It tells you what in your system and running even if you can't see it.

It's valid. You had to get it. It doesn't just show up. Visit the website to unsubscribe to the service.

Basics for Uninstalling Software

Most OS X applications are completely self-contained "packages" that can be uninstalled by simply dragging the application to the Trash. Applications may create preference files that are stored in the /Home/Library/Preferences/ folder. Although they do nothing once you delete the associated application, they do take up some disk space. If you want you can look for them at the above location and delete them, too.

Some applications may install an uninstaller program that can be used to remove the application. If you cannot find the uninstaller then you could download the freeware, Easy Find, to locate files that need to be removed. The places you need to search include:

1. /Home/Library/Applications Support/ folder. Check if the application has created a folder then delete the folder that's in the Applications Support folder.
2. Applications may install a startupitem or a LogIn item. StartupItems are usually installed in the /Library/StartupItems/ folder or the /Home/Library/StartupItems/ folder. Login Items are set in the Users & Groups preferences. Open it in System Preferences, then click on the Login Items tab. Select the item from the list and click on the Delete [-] button to remove it.
3. Some software use startup daemons or agents. Look for them in /Library/LaunchAgents/ and /Library/LaunchDaemons/ or in /Home/Library/LaunchAgents/.

Some applications install a receipt in the /Library/Receipts/ folder. Usually with the same name as the program or the developer. The item generally has a ".pkg" extension. Be sure you also delete this item as some programs use it to determine if it's already installed.

There are many utilities that can uninstall applications. Here is a selection:

1. AppZapper
2. AppDelete
3. Hazel
4. AppCleaner
5. CleanApp
6. iTrash
7. AppBolish
8. AppUninstaller
9. Uninstaller

For more information visit The XLab FAQs and read the FAQ on removing software.

Here are the vendor-provided removal instructions for,Setapp, and Setapp-provided apps:

https://support.setapp.com/hc/en-us/articles/213588369-Uninstalling-applications

Have you tried these instructions?

If these instructions are not working, there’s a link to contact Setapp support by mail.

If Setapp was not acquired,directly from the provider, the dopy could well contain malware.

You’ve mentioned contacting Setapp support, but not whether the posted uninstall sequence was followed. Did you follow the linked instructions posted at the Setapp site to remove the installed apps, and to then the Setapp tool itself?

So to confirm, after the Uninstall from the Help menu, and having selected the remove completely option, and you’ve then rebooted, and the App remains?

if there’s been some other approach used to try to remove the app or a problem with the removal, there’s apparently a removal tool that the Setapp support folks can provide.

This per: https://apple.stackexchange.com/questions/309956/how-do-i-completely-uninstall-s etapp-and-its-helpers-manually

Failing the manual uninstall and the Setapp support tool, MalwareBytes is probably the path out. There are unfortunately a number of uninstallers around, and some of them have caused corruptions and instabilities.

Whatever tool you pick, have complete and external and current backups, first.

The package is apparently from MacPaw, and they’ve offered some other software packages that have occasionally caused issues for folks, this per various posts around the forums.