Same issues here (switched from 2011 Mac Mini with no issues to 2018 Core i5).
Because of the pitiful internal storage in the new units I have a 1Tb SSD (Samsung Evo 960 in a carrier) connected via Thunderbolt port for photo & media, a USB-C hub connected which adds an SD port & a couple of extra USB3 ports (branded Lenovo).
No printers in the vicinity but there is an XBOX One X which is turned off / connected via Ethernet.
The Macs WiFi has been stable throughout but I’ve only owned it for 2 weeks so later versions of OSX may have patched issues here.
On Bluetooth issue, everything just dies. Keyboard / Mouse just bombs out and their green lights flash furiously. Sony WH1000 headphones turn themselves off. Issue lasts for about a minute then slowly recovers itself and things fire back up.
Not or surprised given how glitchy modern tech is, but this seems basic and avoidable. It’s hardly state of the art tech. Is it BT v4 or v5? Surely these latest versions should be evolved, well developed and resilient by now!
Thought Id share as I haven’t managed to fix it yet and get the issue daily.