Unfortunately, you can't remove it (However you could rename it to something else). Here is a workaround to your problem.
1. Make sure all applications you want to manage are in a folder that your users have read only access to (such as /Applications).
2. By default, any properly installed app will have permissions root:admin rwxrwxr-x. If not, make sure they do.
3. In the terminal cd into /Applications/
___.app/Contents/MacOS
4. Run the command: sudo chmod o-r
_____ (Fill in the blank with the name of the app without the .app extention).
Here is the logic behind this. As long as the apps are in a folder the users only have read access to, such as /Applications, the only way they can edit that info.plist file is to copy the app to their home directory and then edit it. You are now preventing this by taking away their read (and therefore copy) ability to the most important part of the application, the executable. Now they will still be able to execute the app but not read/copy it. If they try, they will need to provide an admin code.