Well, I used to run with my first gen 5 gig iPod and it still works. However, I would still be inclined to say that if you run a lot with a hard drive based iPod, you stand a +very good chance+ of shortening it's life span. I'd recommend getting a Shuffle for running or a Nano if your budget extends that far. I opted to go with the Nano and the Nike+ Sport Kit and am very happy.