Here's the solution that worked for me (credit goes to Lawrence Glassman):
Ensure the unit is directly connected to the computer. Ensure COPY MODE is selected on the printer's control panel. In order to resolve this issue we will need to get a clean reinstall by removing all Epson Scan files and reinstalling only the Epson Scan driver from the website.
To completely uninstall the scanner software please follow the steps
below.
UNINSTALL
To ensure that all Epson Scan files have been removed from the
system you would need to check for the following items in the Hard Drive. Pleasenote: Not all files and locations will be present. If you do not find one of the items listed, please continue on with the next step.
1. In HD (Hard Drive), APPLICATIONS - remove EPSON SCAN and
EPSON SCANNER MONITOR, if present
NOTE: If you receive an error that EPSON SCANNER MONITOR cannot
be deleted because it is in use, go into HD, APPLICATIONS, UTILITIES and open ACTIVITY MONITOR. Highlight the EPSON SCANNER MONITOR process and click on QUIT PROCESS to quit the process. Close ACTIVITY MONITOR. You can now go back into the APPLICATIONS folder and delete EPSON SCANNER MONITOR.
2. In HD, LIBRARY, APPLICATION SUPPORT - remove the EPSON SCANNER MODULE folder.
3. In HD, LIBRARY, IMAGE CAPTURE, TWAIN DATA SOURCES - remove the ".ds"
file bearing your scanner's name.
4. In HD, USERS, (YOUR USER NAME), LIBRARY, PREFERENCES - Open
the EPSON folder and then delete the EPSON SCAN folder.
REINSTALL
Once the removal is complete, restart your computer. After the
restart, follow the steps below to download and install the most current Epson Scan driver:
Please note: You will require Stuffit to install the Epson Scan software.
Stuffit is not installed by default on Tiger. If you are not able to install the software, please visit
http://www.stuffit.com/mac/index.html to
download and install Stuffit.
1. Go to www.epson.com and select North America and then USA.
2. Click on DRIVERS AND SUPPORT, select your appropriate product
category and then select your product.
3. Select on MACINTOSH under DRIVERS AND DOWNLOADS and select
the most current version of the EPSON SCAN. Click on DOWNLOAD NOW,
respond to the question, and ACCEPT the licence agreement. The download will now begin.
4. Once the download is complete you will see a EPSONXXXX.SEA.HQX
(XXXX indicates the numbers you will see). Doubleclick on this, and it will
begin expanding the file and then place a EPSONXXXX.SEA icon on your
desktop.
5. Double click on this and click on CONTINUE and CONTINUE again. An installation will begin, and once it is finished, click on OK.
6. You will now see a folder on your DESKTOP labeled EPSONXXXX. Open this folder and double click on the EPSON SCAN INSTALLER. Enter your system password when prompted.
7. Once the EPSON SCAN INSTALLER screen appears, click on the dropdown
arrow beside EASY INSTALL and then select CUSTOM INSTALL.
8. Select only the scanner that you are installing, and then click on
INSTALL. Once the install is finished, click on QUIT.
NOTE: THE FOLLOWING IS FROM THE ORIGINAL STEPS. I HAD TO USE IMAGE CAPTURE FOR THE SCANNER TO WORK
To use the Epson Scan, please follow the steps below:
1. Launch Epson Scan by going into your HARD DRIVE, APPLICATIONS,
and EPSON SCAN.
2. If prompted, select your scanner from the list of models and click OK.
3. In the FILE SAVE SETTINGS window, you can designate the location,
name and type of file the scans will be saved as.
-LOCATION defaults to HD/USERS/(YOUR USER NAME)/PICTURES.
Click CHOOSE if you wish to change this.
-PREFIX determines how the scan will be named. Type any name you
like. You can also designate a start number.
-FILE TYPE dictates what format the scans will be saved in. ie. .JPG,
.TIFF, .PDF, or .PICT)