You can daisy-chain firewire to firewire, and USB to USB, but you cannot daisy chain through different interfaces. When you daisy chain, one HD connects to the computer, and the rest to each other. Whichever interface connects to the computer is the one you need to use between peripherals in the daisy chain.
Sounds like you need a new enclosure; if you get one, try for a FW enclosure. If the HD will connect to eSATA, then you can get an eSATA enclosure along with an eSATA expresscard. USB is the slowest HD interface on the Mac; despite the specs of USB 2, average throughput is much slower in contrast to PCs, where USB 2 and FW400 are about equal.