I am also experiencing this more than annoying problem. Only now it's getting down right dangerous. While saving a file (doesn't matter which app) I selected my Desktop folder from the save dialog, and before I could release the mouse button, the mouse moved completely out of the dialog box and deleted my Desktop folder from the finder sidebar.
For situation, it all started after loading Snow Leopard. I had a bluetooth mouse whose middle click had stopped working prior to upgrade, although I had continued to use it for a week after the upgrade. I brought my mouse back to Apple and they replaced it. I happily set up my new mouse and withing a few minutes, while reading a document on screen (Preview) the mouse started moving down the page without being touched. I lifted the mouse up, and it stopped moving. I put it down and it started moving again. So, back to the Apple store and they replace it once more. Got the new mouse set up and again, the mouse is moving without being touched. It happens with every application I have loaded. Now, the strange thing, if I move the mouse closer to the actual computer, it behaves normally. But since the mini is further back on my desk, I have to really stretch to get the mouse close enough to behave properly. Sometimes the mouse tracks normally in its original position. Sometimes it won't (seems to misbehave more when lots of apps are running.) But moving closer to the mini always makes it behave correctly.