A very good question!! I loaded Docs To Go, Good Reader, and they changed nothing at all.
I was having issues opening a 9.95MB PDF file directly from a corporate website using Safari. Smaller documents (1.2MB) loaded no problem.
The document loads OK on the pc, but not on the iPhone. Also refuses to open using Docs To Go or Good Reader regardless if the file is in a remote folder in a cloud or in a subfolder directly on the iPhone.
A couple people here claim to have opened much larger files than that. I'd be interested in a confirmation that you can open this one:
http://www.stm.info/info/reseau2009.pdf
My thanks in advance