Same thing happening to me. All of a sudden, the Magic Mouse gets unresponsive. Unlike other users have reported, the system doesn't even pop up any message saying connection has been lost. At first, I thought it could be a discharged battery issue. Tried putting in brand new batteries, which was useless. As I don't have any other wired mouse, the only thing I can do is waiting for the bluetooth connection to be reestablished. Sometimes, it can take more than 5 minutes. Really annoying and Apple needs to release a correction as soon as possible.