I had this same thing happen to me recently. I dumped a bunch of movies onto an external drive to free up space, and it happened again! It turned out to be related to a too-large e-mail attachment. I had tried to send an e-mail with a 35MB attachment using Mac Mail, but it wouldn't send because the file was too large for the server. Shortly after this I noticed that a "recovered messages" folder had appeared in my Mail sidebar. This folder was being repeatedly filled with copies of my rejected e-mail. By the time I discovered this, there were over 1600 of them in there. From what I can tell the only way to fix the problem is to remove that account from Mail and then re-create it. I tried clearing the files out manually, and even deleting the whole "Recovered Messages" folder, but it just kept coming back. I hope that helps!