Palm recommends that for the m500 series of handheld organizers, that you install the Palm Desktop 4.2.1 version A, available here:
http://www.palm.com/us/support/macintosh/macdesk421.html
With this handheld, you
need not first install software from the CD-ROM that was supplied with your device, as it does not contain unique software for your device.
After installing the Palm Desktop, Apple recommends that you first synchronize with it prior to configuring and using iSync. Once you've done that, launch iSync and select
Enable Palm OS Syncing… from the Devices menu, and follow the instructions which appear. At the conclusion of this step, your device will appear in iSync. You can then press the Palm icon in its main window to drop down a configuration pane, which lets you specify how iSync interacts with specific contact groups and calendars.
If you intend to synchronize with other devices, including .Mac, you should also open the
Preferences… dialog under the iSync menu, and check or enable all three options under the General tab. Then, each time you synchronize, you should…
• launch iSync
• select Sync Now from beneath the Sync Status icon in your menu bar, and
• press you HotSync button when prompted to do so by the dialog
And, when you've successfully done all this - and find youself unhappy with the manner in which iSync performs - you should consider purchasing and installing the far more flexible, robust, feature-rich and reliable synchronization software from Mark/Space: The Missing Sync for Palm OS. More information about that package is available here:
http://www.markspace.com/missingsync_palmos.php
One caution: The Missing Sync for Palm OS should be installed only after you have successfully synchronized at least once with both the Palm Desktop and with iSync.