Safari 5 Font Rendering Problem
Here is an example of what I see: http://www.theregister.co.uk/2010/06/08/chinainternetstrategy/
Here's a screenshot of the problem, with Safari 5 on the left and Chrome on the right (which doesn't have the problem - weird, I know; they're both WebKit browsers!)
http://yfrog.com/esscreenshot20100608at181p (click the image to view it full-sized)
I've verified all my fonts and resolved all my duplicates.
27" Aluminium iMac (2.66GHz i5, 4GB RAM), Mac OS X (10.6.3), Other computer: 13" 1.6GHz MacBook