Hm, that is interesting ... no 3rd party apps, I mean. You may have said that before and I missed that.
I think we can conclusively rule out hardware issues - just too many similar reports from people with different hardware. Unless there is a little radio chip that some of us got and some of us didn't - possible, but not likely. And there is always the possibility that there are two different pathologies triggered by the same change which could be due to different things.
But be that as it may, you are saying you started completely fresh and loaded NO 3rd party apps and it is still draining. That is extremely interesting. This would mean it is one of the default apps - but we all have them, so it should happen to everybody. Or it is one of the default settings - but then again, why does it only happen to a subset of people??? I am with Peter on this - it does defy logic.
One thing I am now thinking about is interaction with certain routers ... hear me out - that is something that is different between different people who may have the same phone. And at least some reports seemed to indicate that it is related to wireless interaction. And some wireless users reported reception trouble with 12.1.X (truth be told, my performance got worse with 12.1.2 or 12.1.3 - I know because I bought a back-up power pack for the first time in my life - and then it dropped off a cliff with 12.1.4, at least for the first 1.5 weeks, now limping along). That's the best I can offer at this point ... I don't believe in "intermittent" - any kind of electronic system is highly deterministic, if there is a difference in behavior there is a difference in the underlying factors.