Usual reason for email server degradation is a misconfiguration, and that can manifest with various symptoms, sometimes including a tsunami of outbound or relay spam. Other potential issues with a mail server cab range from DNS configuration errors to spam to spam filtering.
If this is macOS with Server.app as I'd suspect, that's best upgraded to High Sierra and to Server.app prior to 5.7.1 and no later. Start planning for your migration off of Server.app, as well. Mail and other services are not available with 5.7.1 and later.
There's also always a decent change of a hardware failure, though those aren't usually tied to a specific time of day.
QuickLook is not related to an email server.
It's usually possible to paste the EtreCheck reply here by opening a reply here, and then using the button that looks like a printed page to open up a text input box that's usually large enough to paste the EtreCheck configuration report.
