How to remove US-U.Openx.net from Safari
This is what worked perfectly for me:
To remove US-U.Openx.net from Safari (recommended by Norton.com)
Reset Safari
Start the Safari browser.
On the Apple menu bar, select History > Clear history > All History > Clear History.
When you clear the browsing history in Safari, it also clears the website data (such as saved passwords and other entries).
On the Apple menu bar, select Safari > Preferences > Extensions > Uninstall
Mac Pro