With the exception of CleanMyMac 3, I don't see any software that normally causes problems. I suggest you increase the amount of RAM you have installed. 4 GB is on the low end for running as much software as you have open on a modern OS version. As a test, try restarting the computer, and don't open any programs except Safari. See if Safari performs more normally.
I would upgrade your RAM to at least 8 GB minimum. The 2 places I’ve seen recommended most to buy reliable RAM are below. I have purchased RAM several times, a MacBook Pro battery, and 2 hard drives from Other World Computing and have always been very satisfied with the product and service. They have on-line instructions on how to replace the RAM. OWC has also tested RAM above what Apple states is the maximum. I had 6GB installed on an early 2008 iMac supposedly limited to 4 GB and noticed an improvement.
Crucial
Other World Computing
Most posters recommend not using cleaning programs. They can destroy normal computer operations.
CleanMyMac3 Uninstall
Check for any remaining associated files using these programs.
EasyFind – Spotlight Replacement
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