The beginning of EtreCheck gives a very solid clue
Adware - Adware detected.
More than one antivirus app - This machine has multiple antivirus apps installed.
Side issue
/etc/hosts - Count: 15 - Corrupt!
This may be a failed attempt at blocking some websites, or an attempt by adware to redirect your web browsing to a different site from what you entered.
And being corrupt means someone did not do a good job of entering the values.
Antivirus apps: Avast and CleanMyMac
Have 2 anti-virus packages just means you spend even more system resources looking for viruses that do not exist, and as neither of these packages detected the Adware, I would say they are not doing a good job.
I would suggest uninstalling them using the vendors uninstall instrucitons
Adware:
Launchd: /Library/LaunchDaemons/com.undoubtingness.net-preferences.plist
Reason: Adware pattern match
Executable: /etc/change_net_settings.sh
If you re-run EtreCheck, there should be a button to remove the adware.
Or you can install MalwareBytes for Mac (written by a fellow forum volunteer). You do not need to keep MalwareBytes installed, because as of today, you only get adware/malware when when you are involved in the installation, so if you do not install any software that did not come from the App Store, then you are not getting any unintended side-installs of adware or malware.
MalwareBytes Anti-Malware
<https://www.malwarebytes.org>
And when you are finished checking (and cleaning) uninstall MalwareBytes
<https://support.malwarebytes.com/docs/DOC-1928>
You have a very long list of 3rd party kernel extensions.
Kernel Extensions:
/Library/Application Support/Roxio
TDIXController.kext (2.0)
/Library/Extensions
TelestreamAudio.kext (Telestream Inc., 1.1.1 - SDK 10.8)
/Library/StartupItems/BRESINKx86Monitoring
BRESINKx86Monitoring.kext (9.0)
/System/Library/Extensions
ApowersoftAudioDevice.kext (1.0.0d1 - SDK 10.6)
IntechFWDeviceTuner.kext (1.0)
ContourShuttle.kext (2.2)
CDSDAudioCaptureSupport.kext (1.2)
EyeTVCinergyXSAudioBlock.kext (1.1)
BoomDevice.kext (1.1 - SDK 10.1)
Terminus.kext (4)
RBIOKitHelper.kext (1.8.0)
M-AudioFireWireBeBoB.kext (1.10.2)
M-AudioUSBMIDISupport.kext (M-Audio USB MIDI Support 1.0)
Motu MIDI Driver.kext (1.3.7)
PACESupportFamily.kext (5.8)
RoxioBluRaySupport.kext (1.1.6)
SonyMagicGateDriver.kext (1.0.0)
/System/Library/Extensions/PACESupportFamily.kext/Contents/PlugIns
PACESupportLeopard.kext (5.8 - SDK 10.4)
PACESupportPanther.kext (5.8 - SDK 10.-1)
PACESupportSnowLeopard.kext (5.8 - SDK 10.6)
PACESupportTiger.kext (5.8 - SDK 10.4)
If you do not actively need these kernel extensions you might consider uninstalling them using the vendor's uninstall instructions. They are consuming RAM and CPU cycles.
You start a lot of processes when you login. If you are having performance issues, maybe consider pruning that list back to the absolute essentials, and start the others only when you actually need them. And of course if you stopped using an item, just stop starting it altogether
Aladdin Path: /Library/StartupItems/Aladdin
ChmodBPF Path: /Library/StartupItems/ChmodBPF
M-Audio FireWire Audio Helper Path: /Library/StartupItems/M-Audio FireWire Audio Helper
M-Audio Firmware Loader Path: /Library/StartupItems/M-Audio Firmware Loader
PACESupport Path: /Library/StartupItems/PACESupport
QuickBackStartupItem Path: /Library/StartupItems/QuickBackStartupItem
rEFItBlesser Path: /Library/StartupItems/rEFItBlesser
RetroRun Path: /Library/StartupItems/RetroRun
SpeedToolsDTStartupItem Path: /Library/StartupItems/SpeedToolsDTStartupItem
TuxeraNTFSUnmountHelper Path: /Library/StartupItems/TuxeraNTFSUnmountHelper