As nearly as I can tell, Full Drive access is not available with OS 10.13 so don't worry about it.
You have one "cleaning" app running and it is older than your computer:
[Running] com.syniumsoftware.CleanAppDaemon.plist (? ef658ad4 - installed 2015-03-25)
These are completely unneeded and interfere with the excellent self-maintenance features you paid Apple to install in the Mac OS. I have seen EtreCheck reports where removing a cleaning app also removed warnings of a failing hard drive.
You also have high RAM-usage apps auto-launching at boot in your User Login Items. With only 8GB of hard-to-upgrade RAM, you really cannot afford that. At least remove Word, Acrobat, and Safari. If Magic Menu and ZoomOpener are system mods, they need to go too.
However the hard drive is, as in most 21.5-inch iMacs, the basic bottleneck. Your read/write scores are unusually low and likely indicate HD troubles:
Performance:
System Load: 1.84 (1 min ago) 1.83 (5 min ago) 1.84 (15 min ago)
Nominal I/O speed: 0.80 MB/s
File system: 120.00 seconds (timed out)
Write speed: 31 MB/s
Read speed: 35 MB/s
We have a 2011 iMac with the same slow 3GBps 5400 rpm mechanical drive and its scores significantly exceed yours:
Performance:
System Load: 1.62 (1 min ago) 1.67 (5 min ago) 1.87 (15 min ago)
Nominal I/O speed: 0.05 MB/s
File system: 38.28 seconds
Write speed: 112 MB/s
Read speed: 91 MB/s
Remove CleanApp per the developers' instructions, restart your Mac and run EtreCheck again. if those read/write scores go up to nearly 100, your computer should run better. If not, the hard drive is truly the problem, and we can address that next.