Catalina wont boot from external SSD
My late 2012 iMac is now running from an external Samsung SSD. It runs fine, but I wanted a more robust drive so I got a OWC SSD 1TB drive and a Mercury Elite Pro Mini enclosure. I have the OWC connected with USB 3. I have downloaded a fresh copy of Catalina from the App store onto the drive, but when it comes to rebooting (picture of keyboard and mouse on screen) it looks like it goes to an old installer or something, because it just hangs and doesn't move. The original HD on the Mac is just used for Time Machine backups now. Could it still have an old installer confusing things?
It worked fine with my Samsung, but not with my OWC, which is, btw, erased and formatted as APFS, same as the Samsung.
What would make this work? Cloaning? Bootable drive?
Thanks in advance.
iMac 21.5", macOS 10.15