I am using a Mac OS Catalina 10.15.5 and have recently migrated information from my old computer using Migration Assistant but when pressing both My Documents folder icon and the Desk Top icon, I get a message saying

brbrown Said:

"Hello. I cleared my Backup drive and started again with a new backup which I was then able to transfer with the Migration Assistant and now all is well. Thanks for your help. Regards.Brian."

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You are welcome - I am glad that it work.

Great job troubleshooting! 👍

brbrown Said:

"I get a message saying,'The original item can't be found'[...]"

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If a restart does not work...

Reinstall the macOS:

Nothing would be deleted. It's just that items that have become corrupted or deleted, would be replaced or reinstalled back to where they should be. Go Here: How to reinstall macOS from macOS Recovery - Apple Support

Important:

Create a Time Machine Backup, First:

Prior to the re-installation of your macOS, be certain to backup your Mac using a Time Machine Backup. That way, you can have something to restore your Mac from, should anything go wrong with the reinstall. Use an external hard drive that is at least 1.5 the total storage capacity.

brbrown Said:

"I am using a Mac OS Catalina 10.15.5 and have recently migrated information from my old computer using Migration Assistant but when pressing both My Documents folder icon and the Desk Top icon on the new computer, I get a message saying,"The original item can't be found". Can anyone help please?"

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Restart your Mac

Having made these changes, you may need to restart the Mac. So, restart it, and see what happens from there.