Hi,
I have been experiencing the same issue on my 2019 iMac.
O/S: Big Sur (11.0.1)
Anti-virus: Avast Security 14.6
Network monitor: Radio Silence 3.0 (Beta)
I have done some research and found the following page (Avast forums) which provides detailed explanations:
https://forum.avast.com/index.php?topic=239798.0
Running the command in Terminal (as instructed) did return both Radio Silence and Avast Antivirus as a source of issues.
Avast has reported the issue to Apple and I do hope they will address it in the upcoming 11.1 release. Avast is also working on some fix in the upcoming 14.7 release.
Meanwhile I have followed Avast's recommendation and disabled their Web Shield for now. Mail is back to normal while Radio Silence (currently in a beta release that is compatible with Big Sur) is running fine.
(@sketchywizard : You may want to restart your computer to test whether Avast + Little Snitch operate normally once Web Shield is disabled, that is exactly what I did and it did fix the issue. Maybe worth a try.)
Hope this helps.