Hi sbenedetto83,
Welcome to Apple Support Communities! We appreciate you reaching out for help with your MacBook Air. We're happy to look into this mouse issue with you, and help in any way we can.
Is this a third-party mouse? You mentioned that your mouse is USB Bluetooth capable. Is this correct? Do you mean that there is a USB dongle attachment that you use with your mouse? Is the mouse able to connect to the Bluetooth feature of your MacBook directly?
What happens if you disconnect any devices or cables plugged into your MacBook, then start up in safe mode, connect your mouse, and test further? Does the issue continue to occur in safe mode?
Here's a guide with the recommended steps to start in safe mode:
How to use safe mode on your Mac - Apple Support
If the issue is not occurring in safe mode, but returns the next time you restart and start up normally, follow these steps to test your login items:
Remove login items to resolve startup problems on your Mac - Apple Support
We're here for you if you've got any questions.
Have a great day!