My Mac has blinking ? Question mark. Try command and R still no responded

Let's start by having you provide us with the exact model of your MacBook is please.

Booting up to a screen with a question mark inside a folder would indicate that your Mac's startup drive is either not available or that it does not contain a working macOS version.

It appears that your Mac is trying to start up in Internet Recovery mode. Regardless, the solution to this issue will potentially be different than that of for the OP. I second Lanny's suggest that you start a new post so that it will get the attention it deserves.

I have the same issue, mac book air a1370, '2010. Nothings works, only with option key I can choose wifi as on screen.

Please start your own posting.

Well, first, you need to tell which exact model your notebook is.