Byeh123 Said:
"hp mouse not working on MacBook Pro: The mouse is not bluetooth. I have to plug the receiving unit into a USB port in order for it the mouse to work."
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Thank you for clarifying.
What to Try:
Try the following. If nothing is of success, then it is likely the mouse, and you should just use an Apple mouse, for compatibility concerns.
Sometimes when changes are made to the system(i.e. Updates), system configurations (i.e. for Ports) become manipulated, technically. So, reset the SMC and NVRAM. Try performing each thrice. It may take sometime, being certain you have the time to perform these resets.
Single out this user by creating a new user, seeing if this works. If it works, then it is a configuration issue with the current user. If it does not work, then it is the macOS giving your the issue.
See if your HP mouse uses drivers directly for macOS. Note that for macOS 10.15 Catalina and after, it takes only 64-bit drivers.
Look at HP's site, seeing if this is meant to be interoperable with a Mac.