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Epson scanner not working with iMac

Failed to open a connection to the device (-9221)

I have been trying to use the scanner on my Epson ET-2600 on my iMac but keep getting the above error message. I've tried the usual on/off, reboot. I've downloaded the printer driver again but all to no avail. I assume it's to do with a recent update to the OS. I'm running mac OS Big Sur 11.6. Any help. to get this working again would be most welcome.

iMac Pro

Posted on Sep 30, 2021 8:19 AM

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9 replies

Sep 30, 2021 8:26 AM in response to TomsMum

I've seen a few solutions to this and similar problems with connections between a Mac and a scanner.


I have a wireless printer/scanner and what solved the problem for me when I had this message was to set IPV6 to Automatic.


Go to: System Preferences > Network > WiFi > Advanced > TCP/IP > Configure IPV6: Automatically


If this doesn't work for you search the forums. There are quite a few other suggestions.



Sep 30, 2021 8:54 AM in response to TomsMum

All of the available drivers for the ET-2600 on Epson's site were released a month before macOS Big Sur was released. The rhetorical question is how Epson could have tested these drivers on any released version of Big Sur? Consequently, there may be Catalina support, but it is little surprise that there are issues with Big Sur, nearly a year after the drivers were posted.


To rid yourself of Epson software dependency once and for all, I suggest that you download the trial VueScan Professional scanning software that supports the ET-2600 without any Epson software or drivers at all. This is paid, non-subscription software.


I purchased VueScan Professional back in 2010 for a Canon scanner that was abandoned by the vendor. That scanner still works with the current version of VueScan on my M1 mini running macOS 11.6. I have never paid VueScan any software upgrade fee in those eleven years. I am not compensated in any way by the VueScan vendor for mentioning their product here.

Sep 30, 2021 9:44 AM in response to VikingOSX

Epson sw works very well (I have an ET-2500 and is still a charm om M1 MacMini w/Big Sur), regardless the releasing date which I do agree is a bit strange even if a developer can work on betas as final driver should be released only when the final version of an OS is released (BTW, they already list the next version of Mac OS on theyr support site. Not serious).

IMHO there's something wrong on TomsMum machine and I'll give an Etrecheck look.

Epson scanner not working with iMac

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